LCNeuro 4/11/23 LCNeuro 4/11/23

Early Path Dominance as a Principle for Neurodevelopment

LCNeuro 8/31/20 LCNeuro 8/31/20

Video: Applying Methods in Statistical Physics Towards Understanding the Brain

Dissertation Talk by Corey Weistuch, Ph.D. (August 2020)

LCNeuro 6/19/19 LCNeuro 6/19/19

Multiscale Modeling of the Brain as a Function of Metabolic Constraints

We are using novel modeling tools to link cellular level insights about energy usage with cognitive level observations about the effects of energy constraint.

LCNeuro 6/19/19 LCNeuro 6/19/19

Metabolism Modulates Global Synchrony in the Aging Brain

Brain aging is associated with hypometabolism and associated global changes in functional connectivity. Using fMRI, we show that brains become globally desynchronized with age. We show that aging shifts the brain away from a critical point, causing marked threshold changes at the whole brain scale to arise.

LCNeuro 6/19/19 LCNeuro 6/19/19

Using Game Theory to Model Resting State Network Dynamics

Using a game theoretic model of resource utilisation, we are able to model the cost of computation and the decisions this drives the brain to make. In doing so, we can learn about one of the major factors constraining the functional organisation of the brain, and how it determines this organisation.

LCNeuro 6/19/19 LCNeuro 6/19/19

Using GLUT-4 antagonist to test the impact of energy constraints on neuronal dynamics and connectivity.

In order to investigate our findings on ketones, collaborators with expertise in electrophysiology conducted further experiments on animal models to look at the microscopic effect of energy constraint and ketone bodies on the cell.